Compounded D-Penicillamine (Depen, Cuprimine)

Penicillamine is a chelating agent/ antidote used for the removal of excess metals from the body in dogs. This medication is primarily used for copper-storage hepatopathies in dogs. D-Penicillamine can also be used for lead poisoning, mercury poisoning, zinc toxicosis, or cystine urolithiasis. While it may also be used in other animals, D-Penicillamine is most commonly used in dogs. This medication will take several doses before you see an effect. The medications full benefit may not be seen until your animal has been on penicillamine for several weeks or months of treatment. However, you should see gradual improvement in your animal’s condition over time. It is important that this medication be given on a regular schedule and that doses are not missed or skipped. Penicillamine does require a prescription from your veterinarian or doctor in order to be dispense. It should be avoided in patients with renal insufficiency. You and your veterinarian/physician should discuss if this is the best treatment option.

Penicillamine is taken orally and can be compounded into the desired strength and flavor that best suits your pet. We compound this medication into suspension and capsules. This medication should be given on an empty stomach at least 30 minutes prior to feeding. It is important that the suspension is measured out precisely to the exact prescribed dosing and is only given as directed by the veterinarian. It is important not to miss any doses of this medication or it may not be effective. If you miss a dose do not double up on the medication. Wait until the next dose is due and follow the normal dosing schedule as directed.

Common side effects include nausea, vomiting, and decrease in appetite. This medication may also lead to a deficiency in pyridoxine (B6). Often it is recommended that a supplement be added to counteract this interaction. Please call your veterinarian immediately as these symptoms persist as it may indicate a serious reaction. Overdoses of this medication can be serious. If you suspect an overdose, contact your veterinarian or poison control.