Compounded Prazosin (Minipress) For Dogs, Cats & Other Pet Animals
Prazosin is an alpha-adrenergic medication used animals and humans. It is used in animals to help a variety of conditions. It can be used to help ease urination by relaxing the lower urinary tract in dogs and cats. It is often used to help passage of urine or bladder stones. Prazosin is also used in dogs to treat high blood pressure or heart failure. It is important to remember that even though the medication takes effect within as little as 1-2 hours after being given, the true benefits of the medication to your animal’s health may not be seen outwardly. This medication should be used in caution in dog breeds that may have certain MDR1 gene mutations. This mutation is commonly found in “white feet” breeds, including collies, Australian Sheppard’s, shelties, and long-haired whippets. Dogs that have this mutation may be overly sensitive to the medicine and could result in toxicity. Prazosin does require a prescription from your veterinarian in order to be dispensed. You and your veterinarian should discuss if this is the best option for your pet.
Prazosin is given orally and can be compounded to the desired strength and flavor that best suits your patient/pet. We compound this medication into suspensions, capsules, and dissolvable tablets (tiny tabs). This medication is best given with food. If the patient vomits after receiving the dose on an empty stomach, the next dose should be given with food to decrease GI upset. If you miss a dose do not double up on the medication. Wait until the next dose is due and follow the normal dosing schedule as directed. You and your veterinarian should discuss if this is the best option for your pet.
Common side effects of prazosin include weakness, lethargy, lack of energy, and gastrointestinal effects such as vomiting. If symptoms worsen or not resolve contact your veterinarian. If your animal experinces rapid heartbeat, hyperactivity, agitation, or increased body temperature contact your vet immediately, as this may be signs of a serious reaction. Overdoses of this medication can be serious. If you suspect an overdose, contact your veterinarian or poison control.